Michael D. Scofield Ph.D
Assistant Professor Dept. of Anesthesiology
Medical University of South Carolina
I am generally interested in the cellular substrates of drug addiction with a focus on the molecular underpinnings of relapse vulnerability. To date, studies in my laboratory have been focused on the corticostriatal pathway, heavily implicated in drug seeking and relapse. One unique aspect of our group is that the studies performed in the lab are designed to isolate and measure aspects of both neuronal and non-neuronal cells in order to gain a better understanding of how the interaction of both cell types contributes to the plasticity linked to addiction.
Specifically, we study the morphological plasticity of astrocytes and neurons using confocal microscopy and viral vector targeting and labeling strategies. In addition, we utilize electroanalytical methods to probe for alterations in glutamate and nitric oxide levels that contribute to the induction of drug seeking in response to conditioned cue exposure.
Recent Frontiers in Neuroscience Conference
Seminar Detailed New Isolation Techniques for Dendritic Spine Heads